Zelan Wei

Credentials:

2011-present	Junior Faculty, Psychiatry, University of Saskatchewan
2010-2011	Research Associate, Psychiatry, University of Saskatchewan
2007-2009	Research Associate, University of Central Florida
2004-2006	Research Associate, Psychiatry, University of Alberta
2000-2004	Post-Doctoral Fellow, Psychiatry, University of Saskatchewan
1995-1998	Ph.D., Pathology and Pathophysiology, Tongji Medical University
1985-1988	M.Sc., Biochemistry and Molecular Biology, Tongji Medical University
1980-1985	M.D., Tongji Medical University

Funding:

2004-2005	Co-PI: Neuroprotective effects of quetiapine: Implications for the treatment of Alzheimer’s disease. AstraZeneca of Canada
2001-2003	Fellowship and operating funds, Canadian Institutes of Health Research (CIHR) and AstraZeneca /Alzheimer Society of Canada partnership grant, titled: Neuroprotective Effects of Antipsychotics: Implications for the Treatment of Alzheimer’s disease.

Publications (2000-2011):

Wei W, Zhang CE, Liu YH, Wang Q, Wei Z, Mousseau DD, Wang JZ, Tian Q, Liu GP (2010) Supplementation of folate/vit-B12 prevent chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficit in aged rats. (submitted: Neurobiology of Aging)
Wei Z, Tu W, Chigurupati S, Belal C, Lu Y, and Chan SL (2010) Chronic nicotine administration disrupts neurogenesis in the dentate gyrus by impairing activation of cyclic AMP-response element binding protein. (under revision: Stem Cells and Development)
Pennington PR, Wei Z, Rui L, Doig J, Graham B, Kuski K, Gabriel GG, and Mousseau DD (2010) Alzheimer disease-related presenilin-1 variants exert distinct effects on monoamine oxidase-A activity in vitro. J Neural Transm (Suppl) (in press).
Chigurupati S, Madan M, Okun E, Wei Z, Pattisapu JV, Mughal MR, Mattson MP, and Chan SL. (2010) Evidence for altered Numb expression in Alzheimer’s disease patients and a triple transgenic mouse model. J Alz Dis (in press)
Kyriazis GA, Belal C, Madan M, Taylor DG, Wang J, Wei Z, Pattisapu JV, Chan SL (2010) Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel. J Biol Chem 285:6811-6825.
Chan SL, Wei Z, Chigurupati S, Tu W (2010) Compromised respiratory adaptation and thermo-regulation in aging and age-related diseases. Ageing Res Rev. 9:20-40.
Cao X, Rui L, Pennington PR, Chlan-Fourney J, Jiang Z, Wei Z, Li XM, Edmondson DE, Mousseau DD (2009) Serine 209 resides within a putative p38 (MAPK) consensus motif and regulates monoamine oxidase-A activity. J Neurochem 111:101-110.
Chigurupati S, Wei Z, Belal C, Vandermey M, Kyriazis GA, Arumugam TV, Chan SL (2009) The homocysteine-inducible endoplasmic reticulum stress protein counteracts calcium store depletion and induction of CCAAT enhancer-binding protein homologous protein in a neurotoxin model of Parkinson disease. J Biol Chem 284:18323-18333.
Wei Z, Chigurupati S, Bagsiyao P, Henriquez A. Chan SL (2009) The brain uncoupling protein UCP4 attenuates mitochondrial toxin-induced cell death: role of extracellular signal-regulated kinases in bioenergetics adaptation and cell survival. Neurotox Res 16:14-29.
Wei Z, Qi J, Dai Y, Bowen W, Mousseau DD (2009) Haloperidol disrupts Akt signalling to reveal a phosphorylation-dependent regulation of pro-apoptotic Bcl-XS function. Cell Signalling 21: 161-168.
Kyriazis GA, Wei Z, Vandermey M, Jo DG, Ouyang X, Mattson MP, Chan SL (2008) Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: Implications for Alzheimer's disease pathogenesis. J Biol Chem 283:25492-25502.
Xu H, Wang H, Zhuang L, Yan B, Yu Y, Wei Z, Zhang Y, Dyck LE., Richardson SJ, He J, Li X, Kong J, Li XM (2008) Demonstration of an anti-oxidative stress mechanism of quetiapine. Implications for the treatment of Alzheimer's disease. FEBS J 275:3718-3728.
Wei Z, Song MS, MacTavish D, Jhamandas JH, Kar S (2008) Role of calpain and caspase in beta-amyloid-induced cell death in rat primary septal cultured neurons. Neuropharmacology 54:721-733.
He J, Luo H, Yan B, Yu Y, Wang H, Wei Z, Zhang Y, Xu H, Tempier A, Li Xi, Li XM (2007) Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease. Neurobiol Aging 30:1205-1216
Cao X, Wei Z, Gabriel GG, Li XM, Mousseau DD (2007) Calcium-sensitive regulation of monoamine oxidative-A contributes to the production of peroxyradicals in hippocampal cultures; implications for Alzheimer disease-related pathology. BMC Neuroscience 8:73.
Dai Y, Wei Z, Sephton CF, Zhang D, Anderson DH, Mousseau DD (2007) Haloperidol induces the nuclear translocation of phosphatidylinositol 3-kinase, but not that of its effector 3'-phosphoinositide-dependent protein kinase 1, to disrupt Akt signaling in PC12 cells. J Psychiatr Neurosci 32:323-330.
Xiao L, Xu H, Zhang Y, Wei Z, Dyck LE, Devon R, Li XM (2007) Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes. Molecular Psychiatry 13:697-708.
Kar S, Wei Z, MacTavish D, Kabogo D, Song MS, Jhamandas JH. (2006) Amyloid ß peptide and central cholinergic neurons: involvement in normal brain function and Alzheimer’s disease pathology in Abeta peptide and Alzheimer’s disease: celebrating a century of research. Collin J. Barrow and David H. Small (Eds.) Springer-Verlag London Ltd pp.159-178.
Hawkes C, Wei Z, Kabogo D, Kar S (2006) Upregulation of IGF-2/M6P receptor and other endosomal-lysosomal markers in cell surviving toxicity. Alzheimer’s & Dementia 2:S246.
Wei Z, Mousseau DD, Dai Y, Li XM (2006) Haloperidol induces apoptosis via the sigma-2 receptor and Bcl-XS. Pharmacogenomics J 6:279-288.
Kolla N, Wei Z, Richardson JS, Li XM (2005) Amitriptyline and fluoxetine protect PC12 cells from cell death induced by hydrogen peroxide. J Psychiatr Neurosci 30:196-201.
Wei Z, Mousseau DD, Richardson JS, Dyck LE, Li XM (2003) Atypical antipsychotics attenuate the neurotoxicity of ?-amyloid (25-35) by modulating Bax and Bcl-XL/S expression and localization. J Neurosci Res 74:942-947.
Wei Z, Bai O, Richardson JS, Mousseau DD, Li XM (2003) Olanzapine protects PC12 cells from oxidative stress induced by hydrogen peroxide. J Neurosci Res 73:364-368.
Qing H, Xu H, Wei Z, Gibson K, Li XM (2003) The ability of atypical antipsychotic drugs vs haloperidol to protect PC12 cells against MPP+-induced apoptosis. Eur J Neurosci 17:1563-1570.
Bai O, Wei Z, Lu W, Bowen R, Keegan D, Li XM (2002) Protective effects of atypical antipsychotic drugs on PC12 cells after serum withdrawal. J Neurosci Res 69:278-283.
Wang YP, Wei Z, Wang XC, Wang Q, Wang JZ (2001) Comparative study of the expression and phosphorylation of neurofilament proteins of brain gray matter in Alzheimer’s disease. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 23:445-449.
Li XT, Wang Q, Wei Z, Yuan YH, Wang JZ (2001) Alzheimer-like protein phosphatase deficiency leads to abnormal phosphorylation and accumulation of neurofilaments. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 23:439-444.
Wang J, Wei Z, Wang Q, Grundke-Iqbal I, Iqbal K (2000) Association of microtubule promoting and binding activity of tau with its phosphorylation sites. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 22:120-123.
Wei Z, Wang D (2000) Effect of antisense oligonucleotides on the TXA2 production of macrophages stimulated by endotoxin. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 22:293-295.
Wei Z, Wang J, Wang D (2000) Alzheimer’s disease and the effect of estrogen. Foreign Med Sci Sect Molecr Biol 22:189-192.
Wei Z, Wang D (2000) Effects of antisense oligonucleotides on the synthesis of thromboxane A2 and in vivo thrombosis. Acta Universitatis Medicinae Tongji 29:90-91.

Dr. Zelan Wei

Credentials:

Funding:

Publications (2000-2011):