Complete list of refereed publications for David R. J. Palmer

N. D. Vetter and D. R. J. Palmer* (2017) Simultaneous measurement of glucose-6-phosphate 3-dehydrogenase (NtdC) catalysis and the nonenzymatic reaction of its product: kinetics and isotope effects on the first step in kanosamine biosynthesis. Biochemistry, 56, 2001-2009. link

M. A. Sowole, S. Simpson, Y. V. Skovpen, D. R. J. Palmer, and L. Konermann* (2016) Evidence for Allosteric Enzyme Regulation via Changes in Conformational Dynamics: An H/D Exchange Investigation of Dihydrodipicolinate Synthase. Biochemistry, 55, 5413-5422. link

Y. V. Skovpen, C. J. T. Conly, D. A. R. Sanders* and D. R. J. Palmer* (2016) Biomimetic design results in a potent inhibitor of dihydrodipicolinate synthase from Campylobacter jejuni. Journal of the American Chemical Society, 138, 2014-2020. link  
* Highlighted in
JACS Spotlights
link

M. M. Galka, N. Rajagopalan, L. M. Buhrow, K. M. Nelson, J. Switala, A. J. Cutler, D. R. J. Palmer, P. C. Loewen, S. R. Abrams, and M. C. Loewen* (2015) Identification of Interactions between Abscisic Acid and Ribulose-1,5-bisphosphate Carboxylase/Oxygenase. PLOS One, 10(7): e0133033. link

S. M. Forget, A. Jee, D. A. Smithen, R. Jagdhane, S. Anjum, S. A. Beaton, D. R. J. Palmer, R. T. Syvitski, and D. L. Jakeman* (2015) Kinetic evaluation of glucose 1-phosphate analogues with a thymidylyltransferase using a continuous coupled enzyme assay. Organic and Biomolecular Chemistry, 13, 866-875. link

C. J. T. Conly, Y. V. Skovpen, S. Li, D. R. J. Palmer* and D. A. R. Sanders* (2014) Tyrosine 110 Plays a Critical Role in Regulating the Allosteric Inhibition of Campylobacter jejuni Dihydrodipicolinate Synthase by Lysine. Biochemistry, 53, 7067-7075. link

D. Bertwistle,  L. Vogt,  H. B. Aamudalapalli,  D. R. J. Palmer and  D. A. R. Sanders* (2014) Purification, crystallization and room temperature x-ray diffraction of inositol dehydrogenase Iolg2 from Lactobacillus casei BL23. Acta Crystallographica F, 70, 979-983. link

K. E. van Straaten, J. B. Ko, R. Jagdhane, S. Anjum, D. R. J. Palmer, and D. A. R. Sanders* (2013) The structure of NtdA, a sugar aminotransferase involved in the kanosamine biosynthetic pathway in Bacillus subtilis, reveals a new sub-class of aminotransferases. Journal of Biological Chemistry, 288, 34121-34130. link

H. Zheng, D. Bertwistle, D. A. R. Sanders  and D. R. J. Palmer* (2013) Converting NAD-specific inositol dehydrogenase to an efficient NADP-selective catalyst, with a surprising twist. Biochemistry, 52, 5876-5883. link

Y. V. Skovpen and D. R. J. Palmer* (2013) Dihydrodipicolinate synthase from Campylobacter jejuni: kinetic mechanism of cooperative allosteric inhibition and inhibitor-induced substrate cooperativity. Biochemistry, 52, 5454-5462. link

N.D. Vetter, D. M. Langill, S. Anjum, J. Boisvert-Martel, R. C. Jagdhane, E. Omene, H. Zheng, K. E. van Straaten, I. Asiamah, E. S. Krol, D. A. R. Sanders, and D. R. J. Palmer* (2013) A Previously-Unrecognized Kanosamine Biosynthesis Pathway in Bacillus subtilis. Journal of the American Chemical Society, 135, 5970-5973. link 
* Highlighted in
JACS Spotlights
link

I. Gabriel*, N. D. Vetter, D. R. J. Palmer, M. Milewska, M. Wojciechowski, S. Milewski (2013) Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition and targeting by an antifungal pro-drug. FEMS Yeast Research, 13, 143-155. link

S. Anjum, N. D. Vetter, J. E. Rubin, and D. R. J. Palmer* (2013) Synthesis of 3,3'-Neotrehalosadiamine and related 1,1'-Aminodisaccharides Using Disarmed, Armed, and Super Armed Building Blocks. Tetrahedron, 69, 816-825. link

M. Fang, A. Macova, K. L. Hanson, J. Kos, and D. R. J. Palmer* (2011) Using substrate analogues to probe the kinetic mechanism and active site of Escherichia coli MenD. Biochemistry, 50, 8712-8721. link

K. E. van Straaten, H. Zheng, D. R. J. Palmer, and D. A. R. Sanders* (2010) Structural Investigation of myo-Inositol Dehydrogenase from Bacillus subtilis: Implications for Catalytic Mechanism and Inositol Dehydrogenase Subfamily Classification. Biochemical Journal, 432, 237-247. link

M. Fang, B. M. Langman, and D. R. J. Palmer* (2010) A stable analogue of isochorismate for the study of MenD and other isochorismate-utilizing enzymes. Bioorganic and Medicinal Chemistry Letters, 20, 5019-5022. link

M. Fang, R. D. Toogood, A. Macova, K. Ho, S. G. Franzblau, M. R. McNeil, D. A. R. Sanders, and D. R. J. Palmer* (2010) Succinylphosphonate esters are competitive inhibitors of MenD that show active-site discrimination between homologous alpha-ketoglutarate-decarboxylating enzymes. Biochemistry, 49, 2672-2679. link

K. E. Van Straaten, D. M. Langill, D. R. J. Palmer and D. A. R. Sanders* (2009) Purification, crystallization and preliminary X-ray analysis of NtdA, a pyridoxal phosphate-dependent aminotransferase from Bacillus subtilis. Acta Crystallographica F, 65, 426-429. link

R. M. Drevland, Y. Jia, D. R. J. Palmer, and D. E. Graham* (2008) Methanogen homoaconitase catalyzes both hydro-lyase reactions in coenzyme B biosynthesis. Journal of Biological Chemistry283, 28888-28896. link

C. P. Phenix and D. R. J. Palmer* (2008) Isothermal titration microcalorimetry reveals the cooperative and noncompetitive nature of inhibition of Sinorhizobium meliloti L5-30 dihydrodipicolinate synthase by (S)-lysine. Biochemistry, 47, 7779-7781. link One of Biochemistry's "most accessed" Rapid Reports of 2008!

C. P. Phenix, K. Nienaber, P. H. Tam, L. T. J. Delbaere, and D. R. J. Palmer* (2008) Structural, functional and calorimetric investigation of MosA, a dihydrodipicolinate synthase from Sinorhizobium meliloti L5-30, does not support involvement in rhizopine biosynthesis. ChemBioChem, 9, 1591-1602. link

K. E. Van Straaten, A. Hoffart, D. R. J. Palmer and D. A. R. Sanders* (2008) Purification, crystallization and preliminary X-ray analysis of inositol dehydrogenase (IDH) from Bacillus subtilis. Acta Crystallographica F, 64, 98-101. link

R. Daniellou, H. Zheng, D.M. Langill, D.A.R. Sanders and D.R.J. Palmer* (2007) Probing the Promiscuous Active Site of myo-Inositol Dehydrogenase using Synthetic Substrates, Homology Modelling, and Active Site Modification. Biochemistry, 46, 7469-7477. link Selected by the Editor as a "Hot Article" for June 2007!

R. Daniellou, J.W. Quail and D.R.J. Palmer* (2006) 4/6-O-(p-Tolylsulfonyl)-myo-inositol. Acta Crystallographica E, 62, o4880-o4881. link

R. Daniellou and D.R.J. Palmer* (2006) Appel-Lee synthesis of glycosyl inositols, substrates for inositol dehydrogenase from Bacillus subtilis. Carbohydrate Research, 341, 2145-2150. link

Y. Jia, T. Tomeo, K. Yamauchi, M. Nishiyama, and D.R.J. Palmer* (2006) Kinetics and product analysis of the reaction catalyzed by recombinant homoaconitase from Thermus thermophilus. Biochemical Journal, 396, 479-485. link

R. Daniellou, H. Zheng, and D.R.J. Palmer* (2006) Kinetics of the reaction catalyzed by inositol dehydrogenase from Bacillus subtilis and inhibition by fluorinated substrate analogs. Canadian Journal of Chemistry, 84, 522-527. link

Y.A. Leduc, C.P. Phenix, J. Puttick, K. Nienaber, D.R.J. Palmer, and L.T.J. Delbaere* (2006) Crystallization, X-ray diffraction, and sturcture solution of MosA, a dihydrodipicolinate synthase from Sinorhizobium meliloti L5-30. Acta Crystallographica F, 62, 49-51. link

Y. Jia, D.R.J. Palmer, and J.W. Quail* (2005) The mono-(S)-alpha-methylbenzylammonium salt of (R)-homocitric lactone. Acta Crystallographica E, 61, o4034-o4036. link

E.A.L. Sieminska, A. Macova, D.R.J. Palmer and D.A.R. Sanders* (2005).  Crystallization and preliminary X-ray analysis of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) synthase (MenD) from Escherichia coli. Acta Crystallographica F, 61, 489-492. link

R. Daniellou,  C.P. Phenix, P.H. Tam, M.C. Laliberte, D.R.J. Palmer* (2005) Stereoselective oxidation of protected inositol derivatives catalyzed by inositol dehydrogenase from Bacillus subtilis. Organic and Biomolecular Chemistry, 3, 401-403. link

D.R.J. Palmer* (2004). Integration of computational and preparative techniques to demonstrate physical organic concepts in synthetic organic chemistry: an example using Diels-Alder reactions. Journal of Chemical Education, 81, 1633-1635. link

P.H. Tam, C.P. Phenix, D.R.J. Palmer* (2004). MosA, a protein implicated in rhizopine biosynthesis in Sinorhizobium meliloti L5-30, is a dihydrodipicolinate synthase. Journal of Molecular Biology, 335, 393-397. link

D.R.J. Palmer,* H.N. Balogh, G. Ma, X. Zhou, M. Marko, S.G.W. Kaminskyj* (2004). Synthesis and anti-fungal properties of novel compounds which target the alpha-aminoadipate pathway. Die Pharmazie 59, 93-98. link

M. Bhasin, J.L. Billinsky, D.R.J. Palmer* (2003). Steady-state kinetics and molecular evolution of Escherichia coli MenD, or (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene synthase, and anomalous thiamin diphosphate-dependent decarboxylase - carboligase. Biochemistry, 42, 13496 - 13504. link

G. Ma and D.R.J. Palmer* (2000). Improved asymmetric syntheses of (R)-(-)-homocitrate and (2R,3S)-(-)-homoisocitrate, intermediates in the alpha-aminoadipate pathway of fungi. Tetrahedron Letters 41, 9209-9212. link

E.A. Taylor, D.R.J. Palmer, J.A. Gerlt* (2001). The lesser ‘burden borne’ by o-succinylbenzoate synthase: an ‘easy’ reaction involving a carboxylate carbon acid. Journal of the American Chemical Society 123, 5824-5825.

D.R.J. Palmer, J.B. Garrett, V. Sharma, R. Meganathan, P.C. Babbitt, J.A. Gerlt* (1999). Unexpected divergence of enzyme function and sequence: “N-acylamino acid racemase” is ortho-succinylbenzoate synthase. Biochemistry 38, 4252-4258.

D.R.J. Palmer, B.K. Hubbard, and J.A. Gerlt* (1998). Evolution of enzymatic activities in the enolase superfamily: partitioning of reactive intermediates by glucarate dehydratase from Pseudomonas putida. Biochemistry 37, 14350-14357.

A. Gulick, D.R.J. Palmer, P.C. Babbitt, J.A. Gerlt and I. Rayment* (1998). Evolution of enzymatic activities in the enolase superfamily: crystal structure of D-glucarate dehydratase from Pseudomonas putida. Biochemistry 37, 14358-14368.

B.K. Hubbard, M. Koch, D.R.J. Palmer, P.C. Babbitt, and J.A. Gerlt* (1998). Evolution of enzymatic activities in the enolase superfamily: characterization of the D-glucarate/galactarate catabolic pathway in Escherichia coli. Biochemistry 37, 14369-75.

D.R.J. Palmer, S.J. Wieczorek, B.K. Hubbard, G.T. Mrachko and J.A. Gerlt* (1997). Importance of mechanistic imperatives in enzyme-catalyzed beta-elimination reactions: Stereochemical consequences of dehydration reactions catalyzed by galactonate dehydratase from Escherichia coli and glucarate dehydratase from Pseudomonas putida. Journal of the American Chemical Society 119, 9580-9581.

P.C. Babbitt,* M.S. Hasson, J.E. Wedekind, D.R.J. Palmer, W.C. Barrett, G.H. Reed, I. Rayment, D. Ringe, G.L. Kenyon, J.A. Gerlt* (1996), The enolase superfamily: a general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids. Biochemistry 35, 16489-16501.

D.R. J. Palmer and J.A. Gerlt* (1996), Evolution of enzymatic activities: multiple pathways for generating and partitioning of a common enolic intermediate by glucarate dehydratase from Pseudomonas putida. Journal of the American Chemical Society 118, 10323-10324.

D.R.J. Palmer, E. Buncel, G.R.J. Thatcher* (1994) Re-evaluation of cyclodextrin as a model of chymotrypsin: acceleration and inhibition of tertiary anilide hydrolysis. Journal of Organic Chemistry 59, 5286-5291.


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