Combinatorial Protein Engineering Laboratory

Protein-protein interactions (PPIs) play an important role in cell signaling and homeostasis. Aberrant signaling, due to overexpression or knockdown of certain proteins, is the hallmark of diseases such as cancer. The ability to identify and monitor these molecular signatures/biomarkers of cancer is essential for prognosis, diagnosis and monitoring disease progression.

 

We are developing biologic affinity reagents that bind specifically to cancer biomarkers. Our lab uses combinatorial protein engineering techniques (such as phage display) to generate new protein-based reagents that bind the target molecule with high affinity and specificity. These reagents when injected in patients can accumulate specifically at the tumor site and can be used as carriers for targeted delivery of drugs and imaging probes to cancer site, for applications in therapy and non-invasive imaging.

 

We thank the following sources for research funding: