Table 1: List of Mitochondrial proteins involved in apoptosis

 

Protein / Class of proteins

Class/ Location/ Activity/ Function

References

Bcl-2

 

 

       Membrane protein in the PTPC

       Antiapoptotic, controls membrane potential and volume homeostasis

PTPC= Permeability Transition Pore Complex

(43, 44, 48, 48, 122, 166, 167)

Bcl-XL

 

 

       Membrane protein in the PTPC

       Antiapoptotic, controls membrane potential and volume homeostasis.

(122, 167, 168)

Bcl-xES

 

       Membrane protein in the PTPC

       Antiapoptotic, controls membrane potential and volume homeostasis

(169)

Nip 3

       Membrane protein in the PTPC

       Enhances inner and outer membrane potential

(170)

Bax

 

 

       Protein translocating to mitochondria

       p53 induced protein

       Pro-apoptotic , makes pores for Cyt C and apoptotic factor release

(43, 48, 166, 170)

Bak

 

       Protein translocating to mitochondria

       Pro-apoptotic , makes pores for Cyt C and apoptotic factor release

(43, 170, 171)

Bad

 

       Protein translocating to mitochondria

       Pro-apoptotic

(43, 167)

Bid

 

       Protein translocating to mitochondria

       Pro-apoptotic

(43, 170, 171)

Bim

       Protein translocating to mitochondria

       Pro-apoptotic

       Enhances outer membrane permiability

(41, 170)

NoxA

       Pro-apoptotic

       p53 induced protein

(172, 173)

Puma

       Pro-apoptotic

       p53 induced protein

(172, 173)

Proline oxidase

       Proapoptotic

       p53 induced protein

       induces inner membrane permeability

       generates reactive oxygen species (ROS)

(174)

p53

       Protein translocating to mitochondria

       Antagonist to Bcl-2/ Bcl-XL

(173)

Cyt C

 

       Proteins released from mitochondria

       Activator of apoptosome

(32, 175)

Hsp 10

       Proteins released from mitochondria

       Co-activator of apoptosome

(176)

Smac/ DIABLO

       Proteins released from mitochondria IAP inhibitor

(6, 122, 171, 177)

Apoptosis Inducing Factor (AIF)

 

       Proteins released from mitochondria

       Antioxidant flavor protein released from mitochondria to promote nuclear DNA fragmentation

(178, 179)

Endonuclease G

       Proteins released from mitochondria

       Promotes nuclear DNA fragmentation

(171)

Omi/ High temperature requirement protein A2 (HtrA2)

       Proteins released from mitochondria

       IAP inhibitor

(180, 181)

Voltage dependent anion channel

(VDAC)

       Membrane protein in the PTPC

       PTP component in the outer mitochondrial membrane

(61, 66, 182)

Adenine nucleotide translocator (ANT)

       Membrane protein in the PTPC

       PTP component in the inner mitochondrial membrane

(47, 92, 183)

Cyclophilin D

 

       Membrane protein in the PTPC

       PTP component in the mitochondrial matrix

(41, 184, 185)

Peripheral benzodiazepine receptor

       Membrane protein in the PTPC

       PTP component in the outer mitochondrial membrane

(98, 102)

Procaspases

       Protein released from mitochondria

       Caspase activtion

(176)