-    at first vet visit
-    prior to entering a household with existing uninfected cats
-    in an existing household prior to admission of a new, uninfected cat
-    prior to their first FeLV vaccinations (the cat may already be infected pre vaccination)

Cats should be vaccinated to protect against a FeLV infection or to prevent a persistent viremia.  Vaccines will vary in their protective effect as their efficacy is questionable and are only indicated for uninfected cats; there is no benefit in vaccinating a FeLV positive cat.  Only at risk populations need to be vaccinated as the vaccine has been associated with the development of sarcomas at the vaccination site.  The efficacy of a vaccine ranges from 20% to 100% (8). 

Types of vaccines include:

-    Killed whole virus
-    Subunit
-    Genetically engineered

Vaccinate uninfected cats in infected cat households.  However, constant exposure to FeLV infected
cats is likely to result in viral transmission regardless of vaccination status.  Physical separation may be necessary.  Separate food and water bowls and inhibit mutual grooming to prevent transmission via saliva.  Housing cats indoors and neutering infected cats will reduce the transmission.  Provide good nutrition and husbandry – avoid raw meat, eggs, and unpasteurized milk to avoid possible secondary infections such as salmonella (3).                                        


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