Human Diseases

In people, prion diseases are not contagious. They can be classified according their development as sporadic, familial, or acquired. Sporadic diseases include sporadic Creutzfeldt-Jakob disease (sCJD) and sporadic fatal insomnia (sFI). Gerstmann-Sträussler-Scheinker disease (GSS), familial fatal insomnia (fFI) and familial CJD (fCJD) are inherited, and kuru, iatrogenic CJD (iCJD) and variant CJD (vCJD) are acquired.

 Prion diseases are progressive neurodegenerative disorders and are invariably fatal. Rates of progression, clinical course and average ages of onset differ between the diseases. The distribution and combination of histopathological findings are quite disease-specific as well.

Unfortunately, there are currently no treatment options. To date, studies involving antivirals, antibiotics, or antibodies have not proven fruitful with respect to a delay or outright prevention of clinical disease (7).

brain1    brain2

Creutzfeldt-Jakob disease (CJD)
Fatal Insomnia (FI)
Gerstmann-Sträussler-Scheinker disease (GSS)

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