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Vaccination against is one of the best ways to protect your cat from calicivirus.  The most common types of vaccines are modified live vaccines and inactivated vaccines.  Modified live vaccines contain a form of the virus that has been treated in some way to weaken its virulence.  Inactivated, or adjuvant inactivated vaccines are vaccines that contain the killed virus along with a component to enhance the reaction once the vaccine has been administered to the cat.

In most cases it is recommended to vaccinate kittens against feline calicivirus at 9 and 12 weeks of age and then follow with a booster one year later.  

Due to the variable nature of feline calicivirus, vaccines may not be totally effective against all strains of the virus.  It is also important to note that although vaccination cannot always prevent infection from occurring, it can prevent the infection from developing into severe disease.  Vaccines also do not provide sterile immunity against calicivirus.  This means that even if a cat has been vaccinated for feline calicivirus, it is still possible for the cat to become infected and shed the virus without ever showing any clinical signs. 

It is also very important when dealing with an infected cat, especially in households with multiple cats, to clean and disinfect contaminated areas to prevent spread to other animals as well as re-infection.